Response, reply; a nuclear process

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1. The first letter of the answer for Response, reply; a nuclear process puzzle is: R

R
 
 
 
 
 
 
 

2. The last letter of the answer for Response, reply; a nuclear process puzzle is: N

 
 
 
 
 
 
 
N

3. The answer to Response, reply; a nuclear process is:

R
E
A
C
T
I
O
N
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