Gist of a meaning, the nub or core of an idea

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1. The first letter of the answer for Gist of a meaning, the nub or core of an idea puzzle is: S

S
 
 
 
 
 
 
 
 

2. The last letter of the answer for Gist of a meaning, the nub or core of an idea puzzle is: E

 
 
 
 
 
 
 
 
E

3. The answer to Gist of a meaning, the nub or core of an idea is:

S
U
B
S
T
A
N
C
E
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