Tissue death, often ends in amputation

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1. The first letter of the answer for Tissue death, often ends in amputation puzzle is: G

G
 
 
 
 
 
 
 

2. The last letter of the answer for Tissue death, often ends in amputation puzzle is: E

 
 
 
 
 
 
 
E

3. The answer to Tissue death, often ends in amputation is:

G
A
N
G
R
E
N
E
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