Safe from disease; not affected by something

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1. The first letter of the answer for Safe from disease; not affected by something puzzle is: I

I
 
 
 
 
 

2. The last letter of the answer for Safe from disease; not affected by something puzzle is: E

 
 
 
 
 
E

3. The answer to Safe from disease; not affected by something is:

I
M
M
U
N
E
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