Something acted upon in a chemical reaction

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1. The first letter of the answer for Something acted upon in a chemical reaction puzzle is: S

S
 
 
 
 
 
 
 
 

2. The last letter of the answer for Something acted upon in a chemical reaction puzzle is: E

 
 
 
 
 
 
 
 
E

3. The answer to Something acted upon in a chemical reaction is:

S
U
B
S
T
R
A
T
E

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