Thickened and hardened skin on hand or feet

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1. The first letter of the answer for Thickened and hardened skin on hand or feet puzzle is: C

C
 
 
 
 
 
 
 

2. The last letter of the answer for Thickened and hardened skin on hand or feet puzzle is: S

 
 
 
 
 
 
 
S

3. The answer to Thickened and hardened skin on hand or feet is:

C
A
L
L
U
S
E
S
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