Brain substances with morphine-like effects

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1. The first letter of the answer for Brain substances with morphine-like effects puzzle is: O

O
 
 
 
 
 
 

2. The last letter of the answer for Brain substances with morphine-like effects puzzle is: S

 
 
 
 
 
 
S

3. The answer to Brain substances with morphine-like effects is:

O
P
I
O
I
D
S

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