A Sam Byers novel or disease with an unknown cause

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1. The first letter of the answer for A Sam Byers novel or disease with an unknown cause puzzle is: I

I
 
 
 
 
 
 
 
 

2. The last letter of the answer for A Sam Byers novel or disease with an unknown cause puzzle is: Y

 
 
 
 
 
 
 
 
Y

3. The answer to A Sam Byers novel or disease with an unknown cause is:

I
D
I
O
P
A
T
H
Y
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