The answer to the U.S. singer with the most #1 hits in the 1980s in CodyCross is MADONNA. CodyCross is an amusing word game. It is a word play game that challenges one's word knowledge in different categories and themes. If this clue had you baffled, you're not alone! Many of the puzzles in CodyCross are pretty tricky, but that's what makes the game so fun.